PLOS Comp. Biology: Viral co-evolution and RMT

Our paper “Co-evolution networks of HIV/HCV are modular with direct association to structure and function”, with A. A. Quadeer and M. R. McKay, has been accepted for publication in PLOS Computational Biology. This is a multi-disciplinary research effort which combines new computational methods based on random matrix theory (RMT) with biology and viral evolutionary concepts to establish exciting insights into the mutational co-evolutionary networks employed by both HIV and HCV to evade immune pressure while remaining functionally fit. The results have important implications as they could enlighten the design of new vaccines against these viruses.  A preprint of this work is available on the link above.